Overload of Inflammatory Molecules “Trapped” in Micro Blood Clots May Cause Long COVID Symptoms – SciTechDaily

Very first evidence of inflammatory micro clots in blood of people struggling with Long COVID: This might be the reason for some of the remaining symptoms experienced by people with Long COVID.
New research indicates that an overload of various inflammatory molecules, literally “trapped” inside insoluble tiny embolism (micro clots), might be the reason for a few of the remaining signs experienced by individuals with Long COVID.

Working with vascular internist Dr. Jaco Laubscher from Mediclinic Stellenbosch (a co-author on the post), they now prepare to perform the exact same analysis on a bigger sample of patients. To date they have actually collected blood from one hundred Long COVID individuals who took part in the Long COVID windows registry which introduced in May 2021, as well as from 30 healthy individuals. The research is funded by the Long COVID Research Charitable Trust, a trust established with an initial contribution made by Mr. Koos Pretorius from ENSafrica. It is intended that this trust will be utilized as a vehicle to raise additional funds for research into the causes and efficient treatment of individuals suffering from Long COVID.

This unexpected finding was made by Prof Resia Pretorius, a researcher in the Department of Physiological Science at Stellenbosch University (SU), when she started taking a look at micro clots and their molecular content in blood samples from people with Long COVID. The findings have given that been peer-reviewed and published in the journal Cardiovascular Diabetology in August 2021.
” We found high levels of different inflammatory particles caught in micro embolisms present in the blood of individuals with Long COVID. A few of the trapped molecules contain clotting proteins such as fibrinogen, in addition to alpha( 2 )- antiplasmin,” Prof Pretorius discusses.
Alpha( 2 )- antiplasmin is a particle that prevents the breakdown of blood clots, while fibrinogen is the main clotting protein. Under typical conditions the bodys plasmin-antiplasmin system preserves a fine balance in between blood clot (the procedure by which blood thickens and coagulate to avoid blood loss after an injury) and fibrinolysis (the procedure of breaking down the fibrin in the coagulated blood to avoid blood clots from forming).
With high levels of alpha( 2 )- antiplasmin in the blood of COVID-19 clients and individuals suffering from Long COVID, the bodys ability to break down the clots are substantially hindered.
Fluorescent picture of healthy blood plasma (left) compared to the micro embolisms in the plasma from a private with Long-COVID on the right. Credit: Resia Pretorius
The insolubility of the micro clots emerged when Dr Maré Vlok, a senior analyst in the Mass Spectrometry Unit at SUs Central Analytical Facilities, noted that the blood plasma samples from individuals with severe COVID and Long COVID continued to deposit insoluble pellets at the bottom of televisions after dilution (a process called trypsinization).
He signaled Prof Pretorius to this observation and she investigated it further. They are now the very first research study group to have actually reported on discovering micro clots in the blood samples from people with Long COVID, utilizing fluorescence microscopy and proteomics analysis, consequently resolving yet another puzzle related to the disease.
Of particular interest is the simultaneous presence of consistent anomalous micro clots and a pathological fibrinolytic system,” they compose in the research study paper. This suggests that the plasmin and antiplasmin balance may be central to pathologies in Long COVID, and offers additional evidence that COVID-19, and now Long COVID, have substantial cardiovascular and clotting pathologies.
Further research is recommended into a regime of therapies to support clotting and fibrinolytic system function in people with remaining Long COVID symptoms.
Dealing with vascular internist Dr. Jaco Laubscher from Mediclinic Stellenbosch (a co-author on the post), they now prepare to carry out the exact same analysis on a bigger sample of clients. To date they have collected blood from one hundred Long COVID individuals who got involved in the Long COVID registry which released in May 2021, along with from 30 healthy individuals. The research study is moneyed by the Long COVID Research Charitable Trust, a trust established with an initial donation made by Mr. Koos Pretorius from ENSafrica. It is meant that this trust will be utilized as a vehicle to raise additional funds for research study into the causes and effective treatment of individuals suffering from Long COVID.
Recommendation: “Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin” by Etheresia Pretorius, Mare Vlok, Chantelle Venter, Johannes A. Bezuidenhout, Gert Jacobus Laubscher, Janami Steenkamp and Douglas B. Kell, 23 August 2021, Cardiovascular Diabetology.DOI: 10.1186/ s12933-021-01359-7.

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